Search for dissertations about: "Hemophilia A and B"

Found 4 swedish dissertations containing the words Hemophilia A and B.

2. 1. HEMOPHILIA A AND B WITH SPECIAL REFERENCE TO INHIBITOR DEVELOPMENT AND EXPERIMENTAL STUDIES OF FACTORS VIII AND IX

   Author : Karin Knobe; Enheten för pediatrisk hematologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; inhibitors; mutations; Factor IX; Factor VIII; coagulation; hemophilia A and B; extracellular fluids; Hematologi; extracellulära vätskor;

   Abstract : The general objective of the research underlying this dissertation was to conduct clinical and basic scientific studies to further elucidate the hemophilia and the coagulation process, with the goal of improving the care of families with these disorders. More specific aims were to evaluate epidemiological, genetic, clinical, and biochemical aspects of the development of inhibitors (antibodies) against FVIII and FIX in Swedish patients with hemophilia A and B (papers I, II, and III). READ MORE

4. 2. Structural and functional studies of factor V in health and disease

   Author : Mårten Steen; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; APC resistance and hemophilia; thrombosis; factor VIII; coagulation; factor V;

   Abstract : The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. READ MORE

5. 3. The N-terminal EGF Module of Coagulation factor IX. Studies of Calcium Binding and Module Interactions

   Author : Kristina Persson; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coagulation FIX EGF module calcium binding interaction; Clinical chemistry; Klinisk kemi;

   Abstract : Coagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. READ MORE

6. 4. Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions

   Author : Jovan P Antovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Thrombin activatable fibrinolysis inhibitor TAFI ; coagulation; fibrinolysis; thrombin; plasmin; factor V Leiden; hemophilia; von Willebrand disease; diabetes mellitus; preeclampsia;

   Abstract : Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis. READ MORE