Search for dissertations about: "Hepatic"

Showing result 1 - 5 of 397 swedish dissertations containing the word Hepatic.

  2. 1. Hepatic ischemia-reperfusion injury

    Author : Melroy Alistair D'Souza; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques to reduce blood loss and other intra-operative manoeuvers during liver resection can cause hepatic I/R injury. READ MORE

  4. 2. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Author : Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE

  5. 3. Hepatic lipase and dolichol esterification

    Author : Pavel J Sindelar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dolichol is one of the mevalonate pathway end products, present in all tissues and cellular membranes. The lipid is a primary alcohol consisting of 16-23 isoprenoid residues and occurs as a free alcohol, monophosphate or fatty acyl ester. READ MORE

  6. 4. Hepatic and Portal Vein Thrombosis : studies on epidemiology and risk factors

    Author : Rupesh Rajani; Sven Almer; Tomas Lindahl; Dominique-Charles Valla; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Budd-Chiari syndrome (BCS) i.e. thrombosis in the hepatic veins and/or inferior vena cava, and portal vein thrombosis (PVT) are rare disorders. Epidemiological data are scarce and previous reports have been from highly specialised referral centres. READ MORE

  7. 5. Hepatic and Peritoneal Colorectal Metastases : Aspects of Prognosis and Treatment

    Author : Haile Mahteme; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Colorectal cancer; lever metastas; peritoneal metastas; intraperitoneal; tumör reduktion; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Although two-thirds of colorectal cancer patients are cured by surgery, approximately 50% of the patients with this disease develop locally recurrent or distant metastases during the course of their illness. The aim of this study was to identify metastatic sites associated with poor prognosis in rectal cancer and then to investigate methods that can prevent the development and growth of metastases and optimise uptake of drugs at these sites in animal models. READ MORE