Search for dissertations about: "Hepatitis C virus"

Showing result 21 - 25 of 104 swedish dissertations containing the words Hepatitis C virus.

  2. 21. Genetic variability of hepatitis B virus in chronic infection

    Author : Charles Hannoun; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; mutation; genotype; phylogeny; ; Recombination; coinfection; interferon; response;

    Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE

  4. 22. Molecular characterization of the hepatitis C virus core protein

    Author : Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Abstract : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. READ MORE

  5. 23. Hepatitis C virus infection : molecular analysis of transmission and immunity

    Author : Tobias Allander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus; Nosocomial transmission; Hemodialysis; Leukemia Envelope glycoprotein gp70; Hypervariable region 1; Antibodies; Phage display; Combinatorial antibody libraries; Neutralization.;

    Abstract : Hepatitis C virus (HCV) is an important cause for chronic liver disease worldwide. Infection by HCV may resolve spontaneously, but in the majority of cases a chronic infection is established, that may result in liver cirrhosis and hepatocellular cancer. READ MORE

  6. 24. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Author : Jesper Waldenström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Abstract : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. READ MORE

  7. 25. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors

    Author : Anja Johansson; Montse Llinàs-Brunet; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Hepatitis C Virus (HCV) is the leading cause of chronic liver disease worldwide as well as the primary indication for liver transplantation. More than 3% of the world’s population is chronically infected with HCV and there is an urgent need for effective therapy. READ MORE