Search for dissertations about: "Hepatocellular carcinoma"

Showing result 1 - 5 of 54 swedish dissertations containing the words Hepatocellular carcinoma.

  1. 1. TGFβ and LXR signaling in hepatocellular carcinoma

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Claudia Bellomo; Aristidis Moustakas; Lars Holmgren; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE

  2. 2. In vitro evaluation of formulations used in the treatment of hepatocellular carcinoma

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emelie Ahnfelt; Hans Lennernäs; Erik Sjögren; Niklas Axén; Jesper Østergaard; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery system; Doxorubicin; Microgel; Emulsion; Hepatocellular carcinoma; Biofarmaci; Biopharmaceutics;

    Abstract : Hepatocellular carcinoma (HCC) causes ~ 600,000 deaths annually, making it the second most deadly cancer form. HCC is classified into five stages and for the intermediate HCC treatment, the two most commonly used drug delivery systems (DDSs) are lipiodol-based emulsions and drug-eluting beads. READ MORE

  3. 3. Prognostic factors and tumor treatments in hepatocellular cancer

    University dissertation from Göteborgs universitet

    Author : Malin Sternby Eilard; Göteborgs universitet.; Gothenburg University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatocellular cancer; prognostication;

    Abstract : Background: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Prognosis is related to tumor burden, liver function, and performance status as well as treatment factors. Accurate prognostication is a requisite for optimal treatment decisions. READ MORE

  4. 4. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). READ MORE

  5. 5. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer Investigations in healthy pigs and liver cancer patients

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elsa Lilienberg; Hans Lennernäs; Erik Sjögren; Niklas Axén; Helen M. Burt; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vivo release; drug delivery systems; local delivery; drug disposition; doxorubicin; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemotherapy infusion; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). READ MORE