Search for dissertations about: "Hereditary cancer"

Showing result 21 - 25 of 94 swedish dissertations containing the words Hereditary cancer.

2. 21. Towards improved management of Lynch syndrome; ovarian cancer profiles, risk perception, knowledge and family perspectives

   Author : Katarina Bartuma; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; Lynch syndrome; family relations; communication; interview; genetic knowledge; risk perception; questionnaire; gene expression profiling; array CGH; hereditary breast and ovarian cancer; mismatch repair;

   Abstract : Lynch syndrome (hereditary nonpolyposis colorectal cancer) is one of the most common hereditary cancer syndromes and predisposes to several cancer types, including cancer of the colorectum, endometrium and ovaries. Cancer develops at an early age and one third of the individuals are affected by a metachronous cancer. READ MORE

4. 22. Intrinsic subtypes and prognostic implications in epithelial ovarian cancer

   Author : Jenny-Maria Jönsson; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; gene expression profiling; Lynch syndrome; targeted deep sequencing; chromatin remodeling; molecular subtypes; endocrine receptors; prognostic factors; tumor heterogeneity;

   Abstract : Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. READ MORE

5. 23. Molecular studies of endocrine tumors : Insights from genetics and epigenetics

   Author : Samuel Backman; Per Hellman; Peter Stålberg; Olov Norlén; Robert Bränström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Carcinoid; Pheochromocytoma; Aldosterone; Cancer; MEN1; Multiple endocrine neoplasia; Medicinsk vetenskap; Medical Science;

   Abstract : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. READ MORE

6. 24. Insights into breast cancer: New familial patterns and identification of a potential predictive marker

   Author : Carolina Ellberg; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; Spider telangiectasias; Heredity; Parental inheritance; Recessive; familial; Breast cancer;

   Abstract : The last proportion of heredity in breast cancer has proven to be somewhat elusive despite massive attempts to identify the associated factors. Approximately 50 percent of breast cancer caused by familial factors is currently explained. READ MORE

7. 25. Genetic and epidemiological studies of hereditary colorectal cancer

   Author : Kristina Cederquist; Henrik Grönberg; Irina Golovleva; Gösta Holmgren; Mef Nilbert; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lynch syndrome; HNPCC; colorectal cancer; endometrial cancer; cancer risk; MSI; MLH1; MSH2; MSH6; genome-wide scan; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

   Abstract : Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) is the most common hereditary syndrome predisposing to colorectal cancer, accounting for 1-3% of all colorectal cancer. This multi-organ cancer predisposition syndrome is caused by mutations in the mismatch repair (MMR) genes, especially MLH1 and MSH2, and to lesser extents MSH6 and PMS2, which lead to widespread genetic instability and thus microsatellite instability (MSI). READ MORE