Search for dissertations about: "Heritable"

Showing result 1 - 5 of 90 swedish dissertations containing the word Heritable.

  2. 1. Heritable epigenetic responses to environmental challenges : Effects on behaviour, gene expression and DNA-methylation in the chicken

    Author : Daniel Nätt; Per Jensen; Adroaldo Zanella; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Phenotypic variation within populations is a crucial factor in evolution and is mainly thought to be driven by heritable changes in the base sequence of DNA. Among our domesticated species we find some of the most variable species on earth today. READ MORE

  4. 2. Heritable modulators of the multiple sclerosis phenotype

    Author : Thomas Masterman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Studies of families in which more than one case of multiple sclerosis (MS) occurs have demonstrated that shared genetic and/or environmental factors appear to modify clinical features of the disease, including rate of progression and disease course. We undertook in the present project to determine to what extent selected genetic factors constitute heritable determinants of the MS phenotype. READ MORE

  5. 3. Molecular epidemiology of complex heritable disease : applications in genomics and metabolomics

    Author : Robert Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Modern high-throughput molecular technologies (collectively referred to as “omic” platforms) are generating unprecedented amounts of data on human variation. The four papers in this thesis each investigate and characterize associations between common, complex, heritable disease, and genetic or metabolomic markers from omic platforms. READ MORE

  6. 4. Heritable TP53-related cancer syndrome in Sweden : characterisation of genotype-phenotype correlation and surveillance

    Author : Meis Omran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Around 25% of all cancers are considered as familial and are caused by an inherited susceptibility to develop certain tumours. But only 5-10% are hereditary and caused by known high risk cancer genes associated with specific cancer risk syndromes. READ MORE

  7. 5. Evidence for adaptive variation at the genes coding for cytosolic phosphoglucose isomerase (PGIC) in Festuca ovina L

    Author : Yuan Li; Biodiversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 3-D protein structure; purifying selection; positive selection; cDNA sequences; local adaptation; alvar grasslands; Festuca ovina; Phosphoglucose isomerase; PgiC loci; SNPs; nucleotide polymorphism; horizontal gene transfer;

    Abstract : The gene (Pgi) encoding the enzyme phosphoglucose isomerase (PGI) which plays a central role in the main pathways of carbon metabolism has been shown to be of adaptive significance in a wide range of different species. Earlier studies of enzyme electromorph variation in the grass Festuca ovina suggest that variation in cytosolic PGI (PGIC) may be involved in the adaptive response of F. READ MORE