Search for dissertations about: "Heterocycles"

Showing result 6 - 10 of 46 swedish dissertations containing the word Heterocycles.

  2. 6. Redefining the essential molecular aspects that drive interactions between small molecules and G-quadruplex DNA

    Author : Måns Andréasson; Erik Chorell; Anna Linusson Jonsson; Jan Kihlberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G-Quadruplexes; DNA; Oncogenes; G4 ligands; heterocycles; macrocycles; organic synthesis; molecular interactions; rational compound design; medicinal chemistry.; medicinal chemistry; läkemedelskemi; organisk kemi; Organic Chemistry;

    Abstract : G-Quadruplex (G4) structures are secondary nucleic acid structures located in guanine-rich regions of DNA and RNA sequences, involved in gene regulation and cellular maintenance. Efforts to target G4s in a therapeutic setting are scarce, mainly due to vague details about the binding interactions between the ligands and the G4 structure combined with the lack of emphasis on drug-like properties early in the ligand development process. READ MORE

  4. 7. Ruthenium-catalyzed C-H Functionalization of (Hetero)arenes

    Author : Karthik Devaraj; Lukasz T. Pilarski; Victor A. Snieckus; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; catalysis; C-H activation; heterocycles; ruthenium; aryne precursor; silylation; gramine;

    Abstract : This thesis concerned about the Ru-catalyzed C-H functionalizations on the synthesis of 2-arylindole unit, silylation of heteroarenes and preparation of aryne precursor.In the first project, we developed the Ru-catalyzed C2-H arylation of N-(2-pyrimidyl) indoles and pyrroles with nucleophilic arylboronic acids under oxidative conditions. READ MORE

  5. 8. Transformations of Nitrosoarenes and Alkynyl Enones : Selective Synthesis of Nitrogen-Containing Compounds

    Author : Angela van der Werf; Nicklas Selander; Gary A. Molander; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; alkynyl enones; catalysis; copper; halogenation; heterocycles; nitrosoarenes; perfluoroalkylation; trifluoromethylation; organisk kemi; Organic Chemistry;

    Abstract : The nitrogen atom plays a unique role in organic chemistry. It is abundantly found in organic materials and is responsible for the activity of many biologically relevant compounds. READ MORE

  6. 9. Synthesis of Nitrogen Heterocycles and Ruthenium Complexes

    Author : Johan Johansson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  7. 10. Synthesis of heterocycles from anthranilic acid and its derivatives

    Author : Per Wiklund; Jan Bergman; Norbert de Kimpe; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anthranilic acid; synthesis; heterocycles; benzodiazepines; HNO nitrosyl ;

    Abstract : Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced industrially for production of dyestuffs and pharmaceuticals. READ MORE