Search for dissertations about: "High Content Screening"

Showing result 1 - 5 of 89 swedish dissertations containing the words High Content Screening.

2. 1. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation

   Author : Karl-Johan Leuchowius; Ola Söderberg; Ulf Landegren; Paul Goldsmith; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation; flow cytometry; high content screening; rolling circle amplification; in situ PLA; single-cell; single-molecule; protein interactions; drug screening; post-translational modifications; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

   Abstract : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. READ MORE

4. 2. Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology

   Author : Obaid Aftab; Mats Gustafsson; Neil Carragher; Uppsala universitet; []
   Keywords : label free vesicle detector; high-throughput; phase contrast microscopy; Library of Pharmacologically Active Compounds; High Content Screening; fluorometric microculture cytotoxicity assay; nuclear magnetic resonance; mass spectrometry;

   Abstract : Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. READ MORE

5. 3. Healthy women or risk patients? : Non-attendance in a cervical cancer screening program

   Author : Marie Oscarsson; Eva Benzein; Barbro Wijma; Eva Johansson; Linköpings universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Non-attendance; screening; cervical cancer; health promotion; improverment; informed consent; Obstetrics and gynaecology; Obstetrik och gynekologi; Omvårdnad;

   Abstract : Women afflicted with cervical cancer who have the highest morbidity and mortality rates have been the least likely to be screened. The overall aim of this research project was to investigate non-attendance in a cervical cancer screening (CCS) program among women with no registered cervical smear during the previous five years. READ MORE

6. 4. Women’s participation in mammography screening

   Author : Tatiana Sterlingova; Maud Lundén; Berit Møller Christensen; Johan Kihlberg; Jönköping University; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; health promotion; mammography screening; participation; women;

   Abstract : This dissertation focuses on women’s participation in mammography screening, which is a vital component of early detection and effective management of breast cancer. All Swedish women in the age group of 40-74 receive an invitation by mail at regular intervals of 18-24 months. READ MORE

7. 5. Visualization of Protein Activity Status in situ Using Proximity Ligation Assays

   Author : Malin Jarvius; Ulf Landegren; Ola Söderberg; Hans van Dam; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; in situ; high content screening; platelet-derived growth factor receptor; rolling circle amplification; protein interactions; in situ PLA; post-translational modifications; drug screening; Molecular biology; Molekylärbiologi; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

   Abstract : In 2001 the human proteome organization (HUPO) was created with the ambition to identify and characterize all proteins encoded in the human genome according to several criteria; their expression levels in different tissues and under different conditions; the sub-cellular localization; post-translational modifications; interactions, and if possible also the relationship between their structure and function.When the knowledge of different proteins and their potential interactions increases, so does the need for methods able to unravel the nature of molecular processes in cells and organized tissues, and ultimately for clinical use in samples obtained from patients. READ MORE