Search for dissertations about: "High throughput biology"
Showing result 21 - 25 of 204 swedish dissertations containing the words High throughput biology.
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21. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing
Abstract : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. READ MORE
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22. Non-canonical ATG8 conjugation in ESCRT-driven membrane remodeling processes
Abstract : ATG8 family proteins have the unique ability to conjugate to membrane lipids. Initially identified as a hallmark of autophagy, ATG8 lipidation is emerging as an important regulator of a growing list of non-degradative cellular functions. READ MORE
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23. Towards comprehensive cellular atlases : High-throughput cell mapping by in situ sequencing
Abstract : With recent technological advancements in single-cell biology, many aspects of individual cells are characterized with unprecedented resolution and details. Cell types in human and model organisms are redefined, and multiple organ-wide atlases are proposed to integrate different types of data to provide a comprehensive view of biological systems at cellular resolution. READ MORE
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24. Phenotypic evolution and adaptive strategies in marine phytoplankton (Coccolithophores)
Abstract : Coccolithophores are biogeochemically important marine algae that interact with the carbon cycle through photosynthesis (CO2 sink), calcification (CO2 source) and burial of carbon into oceanic sediments. The group is considered susceptible to the ongoing climate perturbations, in particular to ocean acidification, temperature increase and nutrient limitation. READ MORE
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25. Regulation of gene expression in fruit flies : how does it start, and will it be remembered?
Abstract : One of the most distinctive features of eukaryotic chromosomes is the bundling of DNA together with functionally associated RNA and proteins in chromatin. This allows huge amounts of DNA to be packed inside the very tiny space of the nucleus, and alterations in the structure of chromatin enable access to the DNA for transcription (“reading” genes by production of RNA copies). READ MORE