Search for dissertations about: "High-Throughput Nucleotide Sequencing"
Showing result 1 - 5 of 19 swedish dissertations containing the words High-Throughput Nucleotide Sequencing.
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1. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing
Abstract : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. READ MORE
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2. Statistical assessment of genomic variability in tumours and bacterial communities
Abstract : Current high-throughput DNA sequencing technologies have the ability to generate large amounts of high-resolution genomic data. The high dimensionality in combination with the substantial levels of technical errors and biological variability typically present in the data make, however, the analysis challenging. READ MORE
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3. Diversity of Skin Infections
Abstract : The identification of infectious agents in cancer has been one of the most rewarding endeavors in cancer research. Currently about 20% of the global cancer burden is linked to an infection. A common characteristic of virus-induced cancer is an increased incidence in immunosuppressed patients, presumably because of impaired host control of virus. READ MORE
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4. Metagenomic Characterization of the Gut Microbiome in Cohorts of Elderly
Abstract : Human gut microbiota plays a vital role in maintaining host health. This thesis aims to investigate the gut microbial population and function using next generation sequencing (NGS) data from faecal samples. Paper I examines the influence of sequencing depth and analysis methods in microbiota profiling using NGS whole genome sequencing (WGS) data. READ MORE
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5. Molecular Tools for Nucleic Acid Analysis
Abstract : Nucleic acid technology has assumed an essential role invarious areas ofin vitrodiagnostics ranging from infectious diseasediagnosis to human genetics. An important requirement of suchmolecular methods is that they achieve high sensitivity andspecificity with a fast turnaround time in a cost-effectivemanner. READ MORE