Search for dissertations about: "Highly active antiretroviral therapy"
Showing result 1 - 5 of 15 swedish dissertations containing the words Highly active antiretroviral therapy.
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1. On HIV-1 infection in the central nervous system
Abstract : HIV-1 (hereafter referred to as HIV) is a neurotropic virus that invades the central nervous system (CNS). The CNS is then susceptible to an acute infection and later to CNS opportunistic diseases and AIDS dementia complex (ADC). HIV does not infect the neurons, and neuropathogenesis is largely mediated by the immune system. READ MORE
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2. Pain and sensory function in HIV-infection : with and without antiretroviral therapy
Abstract : Pain is a common symptom throughout the course of HIV-1 infection, with a prevalence ranging between 30-80%, varying with study methodology and patient selection. Neurogenic pain may appear as a consequence of distal predominantly sensory neuropathy (DSP), a common HIV-1 related neurological complication of late HIV-1 infection, usually during the AIDS-stage of the disease. READ MORE
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3. Preclinical studies of ribozyme-mediated gene therapy for HIV-1
Abstract : Approximately 40 million people are infected with HIV-1 and AIDS is the number one cause of death in Africa as well as, the fourth leading cause of death globally. Patients in developed countries generally receive highly active antiretroviral therapy (HAART), even though the drugs are expensive and sometimes cause side-effects and treatment failure. READ MORE
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4. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring
Abstract : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. READ MORE
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5. Prevention of mother-to-child transmission of HIV-1 using antiretroviral drugs in Dar Es Salaam, Tanzania
Abstract : This thesis describes studies of prevention of mother-to-child transmission (MTCT) of HIV-1 in breast-feeding populations in sub-Saharan Africa by perinatal and postnatal prophylactic antiretroviral therapy (ART) of mothers and infants. The acceptability of HIV counseling and testing in pregnant women and the mortality among HIV-1-infected women during 2 years after delivery was also studied. READ MORE