Search for dissertations about: "HisA"
Found 5 swedish dissertations containing the word HisA.
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1. Life will find a way : Structural and evolutionary insights into FusB and HisA
Abstract : How do microbes adapt to challenges from the environment? In this thesis, two distinct cases were examined through structural and biochemical methods. In the first, we followed a real-time protein evolution of HisA to a novel function. The second case was fusidic acid (FA) resistance mediated by the protein FusB in Staphylococcus aureus. READ MORE
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2. Deciphering molecular mechanisms in the evolution of new functions
Abstract : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. READ MORE
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3. The Importance of Being Promiscuous : Understanding enzyme function, specificity, and evolution through structure
Abstract : Enzymes are known to be amazingly specific and efficient catalysts. However, many enzymes also have so-called promiscuous functions, i.e., they are able to catalyze other reactions than their main one. READ MORE
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4. Evolution of New Genes and Functions
Abstract : To answer major evolutionary questions, we need a better understanding of the effects of mutations on specific functions and organism fitness. The aim of this thesis was to elucidate how new functions evolve and potential trade-offs with the original function. READ MORE
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5. Collaboration and Coordination Challenges in Patient-Centered Care : Models and Informaion Services
Abstract : This thesis reports on research focuses on how to deal with the fact that the organization and processesof today’s health and social care are becoming ever more complex as a consequence of societal trends, including an aging population and an increased reliance on care at home. The overall research goal is to suggest ways in which IT-based solutions can enable and leverage collaboration and coordination insituations where a co-morbid patient is subject to care delivered simultaneously by several different professionals and organizations. READ MORE