Search for dissertations about: "Histo-blood group antigens"

Showing result 1 - 5 of 13 swedish dissertations containing the words Histo-blood group antigens.

  1. 1. Expression of Tissue Antigens in Human Pluripotent Stem Cells and Alterations During Differentiation : Potential application in regenerative medicine for treatment of terminal cell and organ failure

    Author : Karin Säljö; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pluripotent stem cells; Differentiation; Histo-blood group antigens; HLA; Tissue antigens; Sialyl-lactotetra; Cell surface antigens; Transplantation; Regenerative medicine;

    Abstract : The major limiting factor in the treatment of patients with end-stage organ failure is the insufficient number of human organs available for transplantation. An unlimited access to human cells, tissues and organs would also open up possibilities to treat several chronic diseases, such as diabetes, neurological and cardiovascular diseases, affecting millions of patients worldwide. READ MORE

  2. 2. Elucidating Genetic and Biochemical Aspects of the P1 and Sda Carbohydrate Histo-Blood Group Antigens

    Author : Linn Stenfelt; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Blood Group; P1 antigen; Sda antigen; A4GALT; B3GALNT2; glycosyltransferase; red blood cell; transfusion medicine;

    Abstract : Human histo-blood groups are inherited polymorphic variants that occur in the molecular structures on the humanred blood cell (RBC) surface. Introducing foreign RBCs into a recipient lacking an antigen may activate the humoraldefence leading to a hemolytic transfusion reaction. READ MORE

  3. 3. Genetics and Expression of Glycosphingolipids in the P1PK and GLOB Histo-Blood Group Systems

    Author : Julia Westman; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosphingolipid; glycosyltransferase; null allele; GLOB; P1PK; Blood group;

    Abstract : The glycosphingolipid (GSL) antigens in the clinically important P1PK and GLOB blood group systems are present on erythrocytes as well as other tissues and are so-called histo-blood group antigens. Blood group antigens of carbohydrate nature are products of enzymes, so-called glycosyltransferases, adding sugars in a step-wise manner to an acceptor substrate. READ MORE

  4. 4. Studies on the Polymorphism and Transcriptional Regulation of the ABO and P1PK Histo-blood Group Genes

    Author : Britt Thuresson; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood group; ABO; A4GALT; P1PK; Gene regulation; Enhancer;

    Abstract : Antigens of the clinically important ABO and P1PK blood group systems are carbohydrate structures. Thus the underlying genes do not encode antigens directly but glycosyltransferases that add specific sugar molecules to selected precursor chains. READ MORE

  5. 5. Studies of the ABO and FORS Histo-Blood Group Systems: Focus on Flow Cytometric and Genetic Analysis

    Author : Annika Hult; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood Group; ABO; Weak expression; FORS; Flow cytometry;

    Abstract : ABO is the clinically most important blood group system and its antigens are carbohydrate moieties present on the surface of the red blood cell (RBC) but also on other tissues throughout the body. The ABO gene encodes an enzyme, a glycosyltransferase (GT),that adds a terminal monosaccharide to the precursor structure, H antigen, to define the A or B antigens. READ MORE