Search for dissertations about: "Histone deacetylase inhibitor"

Showing result 1 - 5 of 23 swedish dissertations containing the words Histone deacetylase inhibitor.

  1. 1. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man

    Author : Ott Saluveer; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; t-PA; hypertension; fibrinolysis; endothelial function; valproic acid; histone deacetylase inhibitor; atorvastatin;

    Abstract : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. READ MORE

  2. 2. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  3. 3. The Interaction of the Adenovirus E1B-55K Protein with a Histone Deacetylase Complex: Its Importance in Regulation of P53 Protein Functions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tanel Punga; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; E1B-55K; p53; histone acetylation; Sin3; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Abstract : The human tumour suppressor protein p53 is an effective inhibitor of cell growth, by inducing cell cycle arrest and apoptosis. However, p53-induced cell growth inhibition can be detrimental for virus multiplication. Therefore, viruses encode for proteins, which can interfere with the functions of the p53 protein. READ MORE

  4. 4. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Steven Gray; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE

  5. 5. Epigenetic regulation of gene expression in the vascular endothelium

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Mia Magnusson; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

    Abstract : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. READ MORE