Search for dissertations about: "Histone modifications"

Showing result 1 - 5 of 66 swedish dissertations containing the words Histone modifications.

  1. 1. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Author : Santhilal Subhash; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE

  2. 2. Clinical management of pancreatic cancer aided by histone signatures

    Author : Monika Bauden; Lund Kirurgi; []
    Keywords : Pancreatic cancer; Histone modifications; Tumor size; Biomarkers; Tumor; LC MS MS; Nucleosomics; Histone H1.3;

    Abstract : .... READ MORE

  3. 3. Chromatin structure and histone modifications in gene regulation

    Author : Carolina Åstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped in almost two turns around this protein complex. READ MORE

  4. 4. Chromatin, histones, and epigenetic tags

    Author : Elisavet Koutzamani; Ingemar Rundquist; Herbert Lindner; Sergey Belikov; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin; histones; histone variants; epigenetics; histone H4 methylation; linker histone phosphorylation; Medical cell biology; Medicinsk cellbiologi;

    Abstract : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). READ MORE

  5. 5. Genome-wide patterns of histone modifications in fission yeast

    Author : Indranil Sinha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. READ MORE