Search for dissertations about: "Histone modifications"
Showing result 21 - 25 of 77 swedish dissertations containing the words Histone modifications.
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21. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
Abstract : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. READ MORE
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22. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells
Abstract : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. READ MORE
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23. Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast
Abstract : Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic structural unit of chromatin. Multiple levels of chromatin organization are required to compact DNA into chromosomes, to ensure an accurate cell division. READ MORE
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24. The CHD chromatin remodeling factors in schizosaccharomyces pombe
Abstract : Regulation of chromatin structure is essential in a wide variety of processes including transcriptional regulation, recombination, replication, chromosome segregation, development and differentiation. The enzymes that are central in regulating chromatin structure can be classified into two major groups. READ MORE
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25. Human Adipocytes : Proteomic Approaches
Abstract : Type 2 diabetes is characterized by increased levels of glucose in the blood originating from insulin resistance in insulin sensitive tissues and from reduced pancreatic insulin production. Around 400 million people in the world are diagnosed with type 2 diabetes and the correlation with obesity is strong. READ MORE