Search for dissertations about: "Histone"

Showing result 16 - 20 of 284 swedish dissertations containing the word Histone.

  2. 16. Histone modification regulated bysuppressor of Zeste 12 and Ipl1 : Aurora-like kinase in Drosophila

    Author : Anna Larsson; Umeå universitet; []
    Keywords : molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Abstract : Polycomb group (PcG) proteins are a group of genome wide silencers that are crucial for many processes during the development. In Drosophila PcG proteins are organised into four different complexes: PRC1, PRC2, PhoRC and PR-DUB. PRC2 consists of four core proteins: Su(z)12, E(z), Esc and Nurf. READ MORE

  4. 17. Genome-wide patterns of histone modifications in fission yeast

    Author : Indranil Sinha; Karl Ekwall; Karin Dahlman-Wright; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. READ MORE

  5. 18. Histone deacetylases and their co-regulators in schizosaccharomyces pombe

    Author : Rebecka A. Silverstein; Karl Ekwall; Anthony Wright; Fred Van Leeuwen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. READ MORE

  6. 19. The Nucleosome as a Signal Carrying Unit : From Experimental Data to Combinatorial Models of Transcriptional Control

    Author : Stefan Enroth; Jan Komorowski; Claes Wadelius; Rickard Sandberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Next generation sequencing; Nucleosome; Histone modification; Transcriptional regulation; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik; Bioinformatik; Bioinformatics;

    Abstract : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. READ MORE

  7. 20. Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

    Author : Nina Rosenqvist; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; Neurology; neuropsychology; ChIP; rat; transgene; insulator; differentiation; GFP; lentivirus; DNA methylation; histone deacetylation; chromatin; expression; silencing; stem cell; progenitor; gene therapy; neurofysiologi; neuropsykologi; CNS; transplantation;

    Abstract : The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. READ MORE