Search for dissertations about: "Homeobox genes"

Showing result 1 - 5 of 20 swedish dissertations containing the words Homeobox genes.

  2. 1. Biological signature of HER2-positive breast cancer

    Author : Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Abstract : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. READ MORE

  4. 2. The Role of HoxB4 in Hematopoiesis

    Author : Ann Brun; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; adenovirus; gene transfer; knock out; HOXB4; HOXB3; homeobox genes; hematopoietic stem cells; Transcription factors; hematopoiesis;

    Abstract : HOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. READ MORE

  5. 3. Regulatory function of homeobox genes in the development of C. elegans

    Author : Yong-Guang Tong; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The nematode worm Caenorhabditis elegans has been widely used as a genetic model for over 40 years to investigate developmental control genes. In this thesis, I studied the roles of several homeobox genes and a novel RNA binding protein (RBD) in the development of C. elegans to understand the function of these genes in higher organisms. READ MORE

  6. 4. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Author : Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. READ MORE

  7. 5. Genes encoding homeodomain-leucine zipper proteins in Arabidopsis thaliana

    Author : Eva Söderman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant physiology; Växtfysiologi; Plant physiology; Växtfysiologi;

    Abstract : A new class of transcription factors, the homeodomain-leucine zipper (HD-Zip) proteins,have been identified in Arabidopsis thaliana. These proteins contain a homeodomainfollowed by a leucine-zipper motif, a combination so far only found in plants. READ MORE