Search for dissertations about: "Homodimer"

Showing result 11 - 15 of 29 swedish dissertations containing the word Homodimer.

  2. 11. Nanofluidics for Static and Dynamic DNA-Protein Interaction Studies - Repair of Double-Strand Breaks from a Single-Molecule Perspective

    Author : Robin Öz; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Single-molecule; Protein; NHEJ; Dynamic; DNA repair; HR; Biomolecule interactions; Microscopy; Fluorescence; Nanofluidics;

    Abstract : Double-strand breaks (DSBs) is one of the most lethal forms of DNA damage. A single DSB may result in stalling of vital cellular machineries, and thus, requires immediate measures by the cell. READ MORE

  4. 12. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines

    Author : Carina Danielsson; Uppsala universitet; []
    Keywords : Medical sciences; vitamin D analogues; retinoids; cancer cell lines; promoter selectivity; cellregulatory properties; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Abstract : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). READ MORE

  5. 13. Biophysical Studies of Apolipoprotein A-IM and a Partitioning study

    Author : Malin Suurkuusk; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apolipoprotein A-IMilano; Apolipoprotein A-I; Lipoprotein; Lipid; Microcalorimetry; DCS; Denaturation; Guanidine Hydrochloride; Physics; Fysik; Chemistry; Kemi;

    Abstract : The major part of this thesis deals with the similarities and differences in some biophysical properties of apolipoprotein A-I (apo A-I) and the molecular variant apolipoprotein A-IMilano (apo A-IM), and the influence on lipid binding. A model compound partitioning study has also been performed. READ MORE

  6. 14. Probing the Alpha Class Glutathione Transferase Structure. Combinatorial Subunit Studies and Rational Redesign

    Author : Ann Gustafsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Glutathione transferases; rational redesign; enzyme; catalysis; Biokemi; Biochemistry; Biokemi; Molecular Biotechnology; molekylär bioteknik avd f jonfysik ;

    Abstract : The present work concerns two Alpha class enzymes, GST A1-1 and GST A4-4, of the glutathione transferase (GST) family, which are detoxication enzymes catalyzing the conjugation of the tripeptide glutathione with various electrophiles. The GST A1-1 structure was explored for protein engineering purposes and tailored for increased activity toward alkenals. READ MORE

  7. 15. Elucidating the molecular basis of Na+/H+ exchange

    Author : Pascal F. Meier; David Drew; Simon Newstead; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; membrane protein; secondary-active transporter; Solute Carrier Transporter; ion-exchange; sodium proton exchanger; potassium proton exchanger; protein structure; cryo-EM; regulation; biokemi; Biochemistry;

    Abstract : Solute carrier (SLC) transporters are membrane transport proteins, which catalyse the movement of nutrients, ions, and drugs across cell membranes. Here, I will present our contribution to understanding the mechanism of the sodium/proton exchangers (NHE), belonging to the SLC9 family of membrane transporters. READ MORE