Search for dissertations about: "Homovanillic acid"

Showing result 1 - 5 of 13 swedish dissertations containing the words Homovanillic acid.

  2. 1. Cerebrospinal fluid content of 5-hydroxyindoleacetic acid and homovanillic acid in manic-depressive psychosis

    Author : Rolf Sjöström; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Glutamatergic mechanisms in schizophrenia : role of endogenous kynurenic acid

    Author : Linda K Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kynurenic acid, a tryptohan metabolite synthesised in astrocytes, is an endogenous antagonist at glutamate receptors, in particular it blocks the glycine site of the (NMDA)-receptor, and at the a7* nicotinic receptor. The compound has been found to be elevated in the cerebrospinal fluid (CSF) as well as in the postmortem prefrontal cortex of patients with schizophrenia. READ MORE

  5. 3. Redefining suicidal behaviour – Rating scales and biomarkers

    Author : Daniel Lindqvist; Lund Psykiatri; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurobiology; Suicide; attempted; Principal component analysis; Chemokines; Cytokines; Hypothalamic-Pituitary-Adrenal-Axis; Hydroxyindoleacetic Acid;

    Abstract : Risk assessment of suicidal behaviour is one of the most important tasks in clinical psychiatry and a major determinant of subsequent care and treatment selections. To date, suicide risk assessment is based solely on clinical evaluations, which inevitably leads to subjective interpretations and decisions by the psychiatrist. READ MORE

  6. 4. The pathophysiological roles of kynurenic acid and cytokines in psychiatric illness

    Author : Sara Olsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kynurenic acid is an astrocyte-derived tryptophan metabolite and a marker of neuroinflammation that antagonizes N-metyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors in the brain. Increased levels have been found in the cerebrospinal (CSF) and brains of patients with schizophrenia and experimental studies have shown that kynurenic acid bi-directionally influences dopaminergic neurotransmission. READ MORE

  7. 5. Molecular genetic studies on cerebrospinal fluid monoamine metabolites in psychotic patients and healthy individuals

    Author : Dimitrios Andreou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cerebrospinal fluid CSF ;

    Abstract : Dopamine, serotonin and noradrenaline are the major monoamines in the human central nervous system (CNS) and following their basic pathways they are degraded to their major metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively. The cerebrospinal fluid (CSF) concentrations of the three monoamine metabolites (MM) are considered to reflect the monoamine turnover rates in the CNS, are under genetic influence and have been associated with schizophrenia. READ MORE