Search for dissertations about: "Hsf1"

Found 3 swedish dissertations containing the word Hsf1.

2. 1. Controlling protein homeostasis through regulation of Heat shock factor 1

   Author : Anna E. Masser; Claes Andréasson; Marie Öhman; David Pincus; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stress; protein homeostasis; molecular chaperones; heat shock response; Hsf1; Hsp70; Saccharomyces cerevisiae; molekylär biovetenskap; Molecular Bioscience;

   Abstract : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. READ MORE

4. 2. Induction of the heat-shock response by misfolded proteins

   Author : Anna E. Masser; Claes Andréasson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Cells respond to stress by transcriptional changes intended for stress survival and adaption to further stresses. Heat shock is an intensively studied stress condition that induces in a plethora of physiological changes including increased protein misfolding. READ MORE

5. 3. The role of T-type calcium channels in human pancreatic β cell maturity

   Author : Kaixuan Zhao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets (hiPSC-islets). These approaches have also been applied to characterize hyperglycemia-induced dedifferentiation of mature β cells within native human islets grafted into the anterior chamber of the eye (ACE) of immunodeficient mice. READ MORE