Search for dissertations about: "Human detoxification"

Showing result 1 - 5 of 31 swedish dissertations containing the words Human detoxification.

2. 1. Respiratory effects of particulate matter air pollution : studies on diesel exhaust, road tunnel, subway and wood smoke exposure in human subjects

   Author : Maria Sehlstedt; Sandström Thomas; Jamshid Pourazar; Anders Bucht; Steffen Loft; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Airway inflammation; antioxidant; bronchoscopy; detoxification; immunohistochemistry; particulate matter; Environmental medicine; Miljömedicin;

   Abstract : Background: Ambient air pollution is associated with adverse health effects, but the sources and components, which cause these effects is still incompletely understood. The aim of this thesis was to investigate the pulmonary effects of a variety of common air pollutants, including diesel exhaust, biomass smoke, and road tunnel and subway station environments. READ MORE

4. 2. Human copper ion transfer : from metal chaperone to target transporter domain

   Author : Moritz Sebastian Niemiec; Pernilla Wittung-Stafshede; Nigel Robinson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

   Abstract : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. READ MORE

5. 3. Aldehyde toxicity in human oral epithelium

   Author : Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

   Abstract : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. READ MORE

6. 4. Innate immunity of human intestinal epithelium in childhood celiac disease : influences from celiac disease associated bacteria and dietary oats

   Author : Grzegorz Pietz; Marie-Louise Hammarström; Thomas T MacDonald; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac disease; dietary oats; gut microbiota; intestinal epithelium; IEL; IFN-γ; IRF1; IL-18; CXC3L1; inflammasome; permeability; Prevotella jejuni; Lachnoanaerobaculum umeaense; immunologi; Immunology;

   Abstract : Background & Aims: Celiac disease (CD) is a chronic inflammatory small-bowel enteropathy caused by permanent intolerance to gliadin in wheat gluten, and related proteins in ray and barley. It is disputed whether CD patients tolerate oats. The only treatment of CD is lifelong gluten-free diet (GFD). READ MORE

7. 5. Substrate specificities and functional properties of human short-chain dehydrogenases / reductases

   Author : Sheikh Naeem Shafqat; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Short-chain dehydrogenases/reductases (SDRs) constitute a universal superfamily of functionally heterogeneous proteins and participate in the metabolism of steroids, prostaglandins, retinoids, aliphatic alcohols, and xenobiotics. So far, more than 3000 members including species variants and over 60 human SDR genes are deposited in databases. READ MORE