Search for dissertations about: "Human influenza A virus"

Showing result 1 - 5 of 42 swedish dissertations containing the words Human influenza A virus.

2. 1. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

   Author : Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Abstract : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. READ MORE

4. 2. Avian Influenza Virus : Deciphering receptor interactions and their role in interspecies transmission

   Author : Per Eriksson; Patrik Ellström; Björn Olsen; Josef D. Järhult; Åke Lundkvist; Jonas Waldenström; Hans-Dieter Klenk; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; birds; glycobiology; glycovirology; host range; mixing vessel; virus attachment; Medical Virology; Medicinsk virologi;

   Abstract : Influenza A virus (IAV) annually infects approximately 5–15 % of the human population, causing ~500,000 deaths globally. Novel IAVs have emerged and spread pandemically in the human population, but have over time established endemic circulation with reduced pathogenicity causing seasonal influenza. The natural reservoir of IAVs is wild waterfowl. READ MORE

5. 3. Tamiflu in the Water : Resistance Dynamics of Influenza A Virus in Mallards Exposed to Oseltamivir

   Author : Anna Gillman; Josef D Järhult; Björn Olsen; Shaman Muradrasoli; Elena Govorkova; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Influenza A virus; avian influenza; oseltamivir; neuraminidase inhibitors; resistance; environmental; Mallard; waterfowl; Medical Science; Medicinsk vetenskap;

   Abstract : The natural reservoir of influenza A virus (IAV) is wild waterfowl, and all human IAVs have their genetic origins from avian viruses. Neuraminidase inhibitors (NAIs) are currently the best drugs for treatment of human influenza; therefore, the orally available NAI oseltamivir (Tamiflu®) has been stockpiled worldwide as part of pandemic preparedness planning. READ MORE

6. 4. Influenza neuraminidase assembly : Evolution of domain cooperativity

   Author : Diogo da Silveira Vieira da Silva; Robert Daniels; Ron Fouchier; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza; neuraminidase; assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Abstract : Influenza A virus (IAV) is one of the most common viruses circulating in the human population and is responsible for seasonal epidemics that affect millions of individuals worldwide. The need to develop new drugs and vaccines against IAVs led scientists to study the main IAV surface antigens hemagglutinin (HA) and neuraminidase (NA). READ MORE

7. 5. Resistance to neuraminidase inhibitors in influenza A virus isolated from mallards

   Author : Goran Orozovic; Björn Olsen; Johan Lennerstrand; Sigvard Olofsson; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; influenza; mallards; neuraminidase; PCR; sequencing; mutation; oseltamivir; zanamivir; resistance; NAI; antivirals; pandemic; Virology; Virologi; Molecular biology; Molekylärbiologi; Bioinformatics; Bioinformatik; Zoonotisk ekologi; Zoonotic Ecology; Virology; Virologi; Biokemi; Biochemistry;

   Abstract : Influenza A virus belongs to the Orothomyxoviridae family of viruses and is one of the most common pathogens that cause infections of the respiratory tract. The aim of this thesis was to investigate if neuraminidase inhibitor (NAI) Tamiflu® (oseltamivir, OC) and Relenza® (zanamivir, ZA) - related resistance mutations exist in the neuraminidase (NA) gene of viruses collected from wild birds. READ MORE