Search for dissertations about: "Human parathyroid cell line"

Found 5 swedish dissertations containing the words Human parathyroid cell line.

  2. 1. Wnt/β-Catenin Signalling in Parathyroid Tumours

    Author : Peyman Björklund; Gunnar Westin; Göran Åkerström; Tommy Andersson; Uppsala universitet; []
    Keywords : Surgery; Hyperparathyroidism; β-catenin; Mutation; Human parathyroid cell line; LRP5; Alternative splicing; Kirurgi;

    Abstract : Primary hyperparathyroidism (pHPT) due to parathyroid tumours with hypersecretion of parathyroid hormone and hypercalcaemia is a common disease with incompletely understood etiology affecting more than 1 % of the population, primarily postmenopausal women. In secondary hyperparathyroidism (sHPT), parathyroid tumours develop in response to calcium and vitamin D deficiency generally in patients with uraemia. READ MORE

  4. 2. Retinoids and vitamin D in skin and parathyroid glands

    Author : Liu Wei; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; all-trans retinoic acid 9-cis retinoic acid vitamin A. vitamin D. CRBP. CRABP. RAR. RXR. parathyroid hormone. calcium receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Vitamin D3 (VitD3) and retinoids are important factors involved in differentiation and proliferation in many cell systems. Their effects in skin, where retinoids and vitamin D are known to be crucially involved in keratinocyte differentiation and function,, and in the parathyroid, the overall regulatory organ in calcium homeostasis were studied. READ MORE

  5. 3. Functional studies of the multiple endocrine neoplasia type 1 gene

    Author : Lovisa Bylund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEN1; menin; tumor suppressor gene; cancer; RNAi; promoter; expression; cytogenetic; microarray;

    Abstract : The multiple endocrine neoplasia type 1 (MEN1, OMIM 131 100) syndrome is an autosomal dominant trait with a near 100% penetrance and with an estimated prevalence of 2-20/100 000. The syndrome is characterized by neoplasia affecting the parathyroid glands (90-97%), enteropancreatic endocrine tissues (30-80%) and the anterior pituitary gland (15-50%) but tumors arc also found in other, both endocrine and non endocrine tissues. READ MORE

  6. 4. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

    Author : Kenneth B. Jonsson; Uppsala universitet; []
    Keywords : Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. READ MORE

  7. 5. The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin

    Author : Alena Lagumdzija; Karolinska Institutet; Karolinska Institutet; []
    Keywords : h0B; SaOS-2; OXT; AVP; IGF-I; PTH; PTHrP; eNOSKO;

    Abstract : The nonapeptides oxytocin (OXT) and vasopressin (AVP) are mainly produced in the hypothalamus and released into the circulation through the neurohypophysis. Recently, an OXT-receptor was demonstrated in human osteoblast-like (hOB) cells, and it has been suggested that patients with central diabetes insipidus (deficiency of AVP) have decreased bone mass. READ MORE