Search for dissertations about: "Huntington’s disease."

Showing result 21 - 25 of 47 swedish dissertations containing the words Huntington’s disease..

  2. 21. Expression and functional analysis of the SCA7 disease protein ataxin-7

    Author : Anna-Lena Ström; Monica Holmberg; Patrik Brundin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Polyglutamine disease; CAG repeat; Spinocerebellar ataxia type 7; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease characterized by cerebellar ataxia and visual problems due to a progressive and selective loss of neurons within the cerebellum, brainstem and retina. The disease is caused by the expansion of a CAG repeat in the first coding exon of the SCA7 gene, resulting in an expanded polyglutamine domain in the N-terminal part of ataxin-7, a protein of unknown function. READ MORE

  4. 22. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation

    Author : Jovana Belic; Jeanette Hellgren Kotaleski; Arvind Kumar; Abigail Morrison; Arthur Leblois; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortico-striatal circuits; levodopa-induced dyskinesia; Parkinson’s disease; effective connectivity; cross-frequency coupling; corticostriatal network; network oscillations; GABAergic transmission. basal ganglia; striatum; cortex; fast spiking interneurons; medium spiny neurons; neuronal avalanches;

    Abstract : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. READ MORE

  5. 23. Modeling Amyloid Disease in Drosophila melanogaster

    Author : Ina Berg; Per Hammarström; Stefan Thor; Damian Crowther; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Amyloid diseases are caused by protein misfolding and aggregation. To date there are 27 known proteins causing amyloid disorders involving brain and peripheral protein deposition. The proteins involved in this mechanism do not share sequence homology, but the amyloid fibrils share biophysical properties and possibly a common pathogenic mechanism. READ MORE

  6. 24. Computational Dissection of the Basal Ganglia : functions and dynamics in health and disease

    Author : Mikael Lindahl; Jeanette Hällgren Kotaleski; Mark Humphries; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computer Science; Datalogi;

    Abstract : The basal ganglia (BG), a group of nuclei in the forebrain of all vertebrates, are important for behavioral selection. BG receive contextual input from most cortical areas as well as from parts of the thalamus, and provide output to brain systems that are involved in the generation of behavior, i.e. the thalamus and the brain stem. READ MORE

  7. 25. In vivo imaging markers for the characterization of molecular changes in Parkinson and Huntington's disease

    Author : Patrik Fazio; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) and Huntington’s disease (HD) are neurodegenerative disorders characterized by a progressive multi-systemic accumulation of misfolded proteins associated with neuronal dysfunction and neuronal loss. The rationale of this thesis is to examine, by means ofthe state of the art Positron emission tomography (PET) methodology combined with the use of high resolution MRI image molecular changes associated to the early stages of PD and HD. READ MORE