Search for dissertations about: "Huntington’s disease"
Showing result 1 - 5 of 47 swedish dissertations containing the words Huntington’s disease.
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1. Communication breakdown - synaptic dysfunction in Huntington's disease
Abstract : Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for 15-20 years. To date no effective treatment is available for curing the disease. HD primarily affects the striatum, cerebral cortex and hypothalamus. READ MORE
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2. Mapping the Huntington's disease process using cerebrospinal fluid analysis
Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE
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3. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology
Abstract : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). READ MORE
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4. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease
Abstract : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. READ MORE
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5. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease
Abstract : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. READ MORE