Search for dissertations about: "Hypercholesterolemia"

Showing result 11 - 15 of 57 swedish dissertations containing the word Hypercholesterolemia.

  2. 11. Immune mechanisms in atherosclerosis : the role of T cells in murine models of atherosclerosis

    Author : Xinghua Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; inflammation; murine models; low density lipoprotein; lipoprotein oxidation; T lymphocyte; T-cell antigen receptors; hypercholesterolemia; autoantibodies; T-cell cytokines; immunization; cardiolipin;

    Abstract : Atherosclerosis is an inflammatory disease. Much interest has been focused on the immune responses in the pathogenesis of the disease. The role of T cells in the development of atherosclerosis was therefore investigated in murine models in this study. READ MORE

  4. 12. Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone

    Author : Paolo Parini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : aging; atherosclerosis; bile acids; estrogen; estrogen receptor; cholesterol; growth hormone; growth hormone receptor; cholesterol 7[alpha]-hydroxylase; high density lipoprotein; hydroxy-methylglutaryl-coenzyme A reductase; hormones; hypercholesterolemia; hypophysectomy; insulin-like growth factor-I; low density lipoproteins;

    Abstract : Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk factors for atherosclerosis. READ MORE

  5. 13. The importance of arginase for vascular dysfunction in patients with glucose and lipid abnormalities

    Author : Oskar Kövamees; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Introduction: Endothelial dysfunction is one important mediator behind atherosclerosis. Maintained bioavailability of nitric oxide (NO) is critical to keep the fragile balance of endothelial function. Reduced NO arise from reduced production or increased elimination of NO. READ MORE

  6. 14. Hepatocyte transplantation : experimental and clinical studies

    Author : Carl Jorns; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hepatocyte transplantation is an experimental treatment for patients with end-stage liver disease and inborn metabolic liver disorders. Studies in animal models and human trials have shown that allogenic hepatocytes infused through the portal vein physiologically integrate into the liver parenchyma, replacing missing liver function. READ MORE

  7. 15. Therapeutic myocardial angiogenesis and its pharmacological modulation

    Author : Anwar J Siddiqui; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; arteriogenesis; ischemic heart; vascular endothelial growth factor; angiopoietin and receptor;

    Abstract : Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of combined angiogenic factors. READ MORE