Search for dissertations about: "Hypoxia tolerance"

Showing result 1 - 5 of 14 swedish dissertations containing the words Hypoxia tolerance.

  2. 1. Tolerance and injury mechanisms in the developing CNS

    Author : Malin Gustavsson; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; neonatal; brain; PARP-1; tolerance; global gene expression; apoptosis; cerebral blood flow;

    Abstract : The pathophysiological mechanisms underlying the development of hypoxic-ischemic (HI) brain injury has been the subject of extensive research yet a neuroprotective strategy to limit its progression is lacking.OBJECTIVES: The aim of the present thesis was to obtain a better understanding of the mechanisms involved in neonatal HI, specifically to study I) the involvement of Poly ADP-ribose) polymerase (PARP)-1 in HI, II) the effect of hypoxic PC on brain injury and function after HI in the long-term perspective, III) the effect of hypoxic PC on global gene expression, in particular the involvement of apoptosis related genes, and IV) the vascular response to hypoxic PC. READ MORE

  4. 2. Protective Responses to Freediving Reveal High-Altitude Tolerance

    Author : Pontus Holmström; Erika Schagatay; Angelica Lodin-Sundström; Harald K. Engan; Ola Eiken; Mittuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acclimatization; Acute Mountain Sickness; Adaptation; Apnea; Breath-hold diving; Cardiovascular diving response; High-altitude; Hypoxia tolerance; Spleen; Acklimatisering; Andhållningsdykning; Anpassning; Apné; Kardiovaskulära dykresponsen; Hög höjd; Hypoxitolerans; Hög-höjdssjukdom; Mjälte; Syrebärande kapacitet;

    Abstract : High-altitude mountaineers - just as freedivers - are exposed to hypoxia. During freediving, the diving response leads to reduced oxygen consumption, and splenic contraction increases circulating hemoglobin concentration (Hb), which enhances freediving performance. READ MORE

  5. 3. Roles of Heparan Sulfate in Amyloid-β Pathology and Hypoxia

    Author : Elina Hjertström; Jin-ping Li; Ulf Lindahl; Sally Stringer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; Alzheimer s disease; Aβ; Proteoglycan; Heparanase; Amyloid; Hypoxia; Cancer; Spalax; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate (HS) is a highly sulfated polysaccharide expressed on the cell surface and in the extracellular matrix, interacting with a large number of proteins. HS is implicated in human diseases, including different types of cancer and amyloid diseases such as Alzheimer's disease (AD). READ MORE

  6. 4. Molecular and Metabolic Aspects of Plant and Bacterial Salt Tolerance

    Author : Peter Olsson; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; metabolism; gamma-aminobutyric acid; Nicotiana tabacum; salinity; hypoxia; heamoglobin; microarray; glycine betaine; NaCl; GABA; Vitreoscilla; calmodulin; Esherichia coli; tobacco; Biokemi; Metabolism; Biochemistry; Arabidopsis;

    Abstract : Salt stress is one of the historically as well as potentially largest agriculture problem humans have faced. Researchers have investigated and tried to solve this problem for a long time. Over 20 reviews have been written on this topic the last five years. READ MORE

  7. 5. Genetically Engineered Plants: Improved stress tolerance, growth and facilitated protein purification

    Author : Gösta Lilius; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glycine betaine; gene; freezing; flooding; drought; dicoteledones; desiccation; compatible solutes; cold; choline dehydrogenase; chill; CDH; betaine; betA; alkaloids anoxia; affinity purification; affinity tags; handles; hemoglobin; hypoxia; low temperatu; Biotechnology; Bioteknik;

    Abstract : Heterologous genes were expressed in plants in which the overall goal was to increase the value of the final crop. Various aspects were explored and evaluated, such as improving the stress tolerance, enhancing the availability of oxygen in growing cells and producing rare proteins with increased degrees of purity. READ MORE