Search for dissertations about: "Hypoxic signalling"

Showing result 1 - 5 of 16 swedish dissertations containing the words Hypoxic signalling.

  2. 1. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways

    Author : Magnus J. Fredriksson; Georg Breier; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Abstract : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. READ MORE

  4. 2. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression

    Author : Karthik Aripaka; Maréne Landström; Jonas von Hofsten; Carl-Henrik Heldin; Ruth Palmer; Lars-Gunnar Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRAF6; HIF-1α; HIF-2α; HIF-3α; ALK5; Wnt3a; Hypoxic signalling; TGF-β; zebrafish; β-Catenin; Pathology; patologi; Oncology; onkologi;

    Abstract : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. READ MORE

  5. 3. Roles of Notch signalling in early embryonic development

    Author : Heather Main; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Metazoan embryonic development requires a complex interplay of morphological processes coordinated with self-renewal and differentiation to correctly specify and maintain body cell types in the correct location. Notch signalling is a metazoan specific arbiter of cell fate decision processes, known to control lateral inhibition and asymmetric cell division processes throughout the metazoa and in the development of all metazoan organs. READ MORE

  6. 4. A multifactorial approach to targeting signalling pathways in diabetic foot ulcers

    Author : Sampath Kumar Narayanan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is hyperglycemia, and its negative effects on normal signaling pathways is still being investigated. READ MORE

  7. 5. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer

    Author : Johanna Welch; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulphate proteoglycans; cancer; hypoxia; polyamines; microvesicles; anti-angiogenic therapy; angiogenesis;

    Abstract : Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. READ MORE