Search for dissertations about: "IDH1"

Showing result 1 - 5 of 8 swedish dissertations containing the word IDH1.

  2. 1. Genotype-phenotype studies in brain tumors

    Author : Soma Ghasimi; Ulrika Andersson; Beatrice Melin; Roger Henriksson; Clemens Dirven; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Meningioma; SNP; IHC; FISH; LRIG2; EGF; EGFR; ERBB2; ER; CDKN2A B; IDH1; onkologi; Oncology;

    Abstract : Meningioma and glioma are the most common primary brain tumors, but their etiologies are largely unknown. Although meningioma is usually benign, their intracranial location can lead to lethal consequences, and despite progress in surgery, radiotherapy, and chemotherapy the prognosis for patients with glioma remains poor. READ MORE

  4. 2. Prognostic markers in acute myeloid leukemia : A candidate gene approach

    Author : Ingrid Jakobsen; Kourosh Lotfi; Henrik Gréen; Anna Fyrberg; Christian Thiede; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. READ MORE

  5. 3. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Author : Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE

  6. 4. Molecular genetic studies on Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia - with focus on prognostic markers

    Author : Kerstin Willander; Peter Söderkvist; Mats Linderholm; Kourosh Lotfi; Sören Lehmann; Linköpings universitet; []
    Keywords : ;

    Abstract : The present thesis is focused on the prognostic value of genetic variations and alterations in the initiation and development of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) patients. Several prognostic markers based on genetic or chromosomal aberrations are today used in clinic in these heterogeneous diseases. READ MORE

  7. 5. Prognostic and biological implications of epigenetic changes in leukemia

    Author : Stefan Deneberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce. We conducted two retrospective studies in AML. READ MORE