Search for dissertations about: "IFN type 1"

Showing result 1 - 5 of 147 swedish dissertations containing the words IFN type 1.

2. 1. Enterovirus Infections of β-Cells : A Mechanism of Induction of Type 1 Diabetes?

   Author : Anna-Karin Berg; Gun Frisk; Torsten Tuvemo; Arne Andersson; Merja Roivainen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; enterovirus; type 1 diabetes; β-cells; human pancreatic islets; picornavirus; chemokines; nitric oxide; Pediatrik; Paediatric medicine; Pediatrisk medicin;

   Abstract : The process of β-cell destruction that leads to type 1 diabetes (T1D) is incompletely understood and it is believed to be a result of both genetic and environmental factors. Enterovirus (EV) infections of the β-cells have been proposed to be involved, however, the effects of EV infections on human β-cells have been little investigated. READ MORE

4. 2. The Importance of CTLA-4 and HLA Class II for Type 1 Diabetes Immunology

   Author : Carl-Oscar Jonson; Johnny Ludvigsson; Maria Faresjö; Dan Holmberg; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; Genetics; Diabetology; Diabetologi;

   Abstract : Type 1 Diabetes (T1D) is a serious chronic disease that results from an autoimmune destruction of the insulin-producing beta cells. Sweden has the second highest incidence of T1D in the world, and it affects more and more children each year. Genes controlling key functions of the immune system regulation of autoimmunity has been associated to T1D. READ MORE

5. 3. Immunological strategies for counteracting type 1 diabetes focusing on IL-35 producing regulatory immune cells

   Author : Zhengkang Luo; Kailash Singh; Stellan Sandler; Per-Ola Carlsson; Martin Blixt; Lina Thorvaldson; Arnaud Zaldumbide; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Regulatory T cell; Regulatory B cell; Interleukin-35; Immunologi; Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

   Abstract : Type 1 diabetes (T1D) is an autoimmune disease where pancreatic β-cells are attacked by immune cells. Regulatory T (Treg) cells play critical roles in suppressing immune responses and their involvement have been intensively studied in T1D. Low dose IL-2 has been proposed to selectively boost Treg cells in T1D, with only limited success. READ MORE

6. 4. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

   Author : Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

   Abstract : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. READ MORE

7. 5. Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease

   Author : Kailash Singh; Thomas Mandrup-Poulsen; Uppsala universitet; []
   Keywords : IL-35; regulatory T cells; type 1 diabetes; LADA; kidney and diabetic nephropathy; Medicinsk vetenskap; Medical Science; Immunologi; Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

   Abstract : Type 1 diabetes (T1D) is etiologically considered as an autoimmune disease, where insulin-producing β-cells are damaged by autoimmune attacks. Regulatory T (Treg) cells are immune homeostasis cells. In the present thesis I aimed to investigate the role of Treg cells and other immune cells in the early development of T1D. READ MORE