Search for dissertations about: "IFN- g"

Showing result 16 - 20 of 113 swedish dissertations containing the words IFN- g.

  2. 16. Bioactive leishmanicidal alkaloid molecules from Galipea longiflora Krause with immunomodulatory activity

    Author : Jacqueline Calla-Magariños; Carmen Fernández; Marita Troye-Blomberg; Geneviève Milon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Leishmania infection; Leishmaniasis; herbal medicine; natural products; Galipea longiflora Krause; Evanta; cytokines; IFN-gamma; dendritic cells; inflammation; meglumine antimoniate; immunologi; Immunology;

    Abstract : According to WHO, leishmaniasis is endemic in 98 countries, and has been placed ninth in a global analysis of infectious diseases. Treatment of leishmaniasis is based on pentavalent antimonials but toxicity and developing resistance have been reported. READ MORE

  4. 17. Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission

    Author : Kristina S Vikman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytokines; interferon-gamma; dorsal horn; hypersensitivity; nociceptive transmission; pain; GluR1; AMPA receptor; disinhibition; spontaneous activity; primary cell culture; two-compartment model; spinal cord.;

    Abstract : Immune cytokines have been implicated as important neuromodulators, contributing to neuronal plasticity both in the adult and developing nervous system. In addition, they have been assigned a potential role in the generation of pathological pain, which may occur as a severe symptom following disease states in the nervous system. READ MORE

  5. 18. Studies of the recognition and activation of natural killer cells

    Author : Clas Une; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; activation; cytotoxicity; IFN-[gamma] IFN-[alpha] [beta]; IL-12; G-PI; MHC class I;

    Abstract : Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other cells upon contact. Killing requires engagement of germline encoded receptors that mediate positive and negative signals. READ MORE

  6. 19. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

    Author : Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

    Abstract : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. READ MORE

  7. 20. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

    Author : Edward Visse; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. READ MORE