Search for dissertations about: "IFNalpha"
Showing result 1 - 5 of 11 swedish dissertations containing the word IFNalpha.
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1. Arthritogenecity of RNA and its degradation products
Abstract : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). READ MORE
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2. Host control of intracellular bacterial infections
Abstract : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. READ MORE
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3. Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection
Abstract : Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish chronic infection. READ MORE
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4. On the pro-apoptotic signaling induced by interferon-alpha
Abstract : Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used as an active drug in the treatment of malignant diseases for almost five decades. It has shown beneficial results in several hematological malignancies, as well as solid tumors, including hairy cell leukemia, multiple myeloma, chronic myeloid leukemia, renal carcinoma and malignant melanoma. READ MORE
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5. To catch a killer : on the mechanisms of interferon alpha induced apoptosis
Abstract : A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances induce apoptosis is still incomplete, and so is the reason for the great variation in cellular sensitivity to these drugs. READ MORE