Search for dissertations about: "IGF receptor"

Showing result 1 - 5 of 129 swedish dissertations containing the words IGF receptor.

  2. 1. The growth hormone receptor and growth hormone sensitivity in man

    Author : Ruth Wickelgren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GH sensitivity; GH receptor; quantitative RT-PCR; IGF-I; skeletal muscle; adipose tissue; tissue-specific; promoter; 5´-untranslated region; psoriasis; epidermis;

    Abstract : It is well established that the response to endogenous and exogenous growth hormone (GH) varies between individuals. For example, conditions with increased catabolic rate, such as trauma, sepsis and surgery, are believed to be associated with acquired GH insensitivity. READ MORE

  4. 2. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat

    Author : Kristina Wallenius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin-like growth factor I IGF-I ; interleukin-6 IL-6 ; growth hormone GH ; GH releasing factor GHRF ; GH secretagogue GHS ; receptor; leptin; insulin; glucose; intracerebroventricular ICV ; dual-energy X-ray absorptiometry DXA ; indirect calorimetry.;

    Abstract : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. READ MORE

  5. 3. CNS Targets for GH and IGF-1 : Emphasis on Their Regulation in Relation to Cognitive Processes

    Author : Madeleine Le Grevès; Fred Nyberg; Anders Hallberg; Sigbritt Werner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Central nervous system; Growth hormone; Insulin-like growth factor-1; Receptor mRNA regulation; N-methyl-D-aspartate receptor mRNA; Morris water maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Abstract : The interest for the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and its role in the central nervous system (CNS) has grown during the past decade. GH has been associated with psychological functions as sleep, mood, general well-being and learning and memory. READ MORE

  6. 4. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Author : Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Abstract : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. READ MORE

  7. 5. Early effects of castration therapy in non-malignant and malignant prostate tissue

    Author : Nina Ohlson; Pernilla Wikström; Anders Bergh; Pär Stattin; Marja Nevalainen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; human biopsies; androgen ablation; stroma; epithelium; micro-dissection; PSA; IGF-1; IGF-R1; AR; Pathology; Patologi;

    Abstract : Early Effects of Castration Therapy in Non-malignant and Malignant Prostate Tissue BACKGROUND. Androgen ablation, the standard treatment for advanced prostate cancer, results in increased apoptosis, decreased cell proliferation and subsequent involution of the prostate gland. READ MORE