Search for dissertations about: "IGF-1R"

Showing result 1 - 5 of 42 swedish dissertations containing the word IGF-1R.

  1. 1. Molecular function and targeting of β-arrestins in cancer

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Huiyuan Zheng; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1R;

    Abstract : In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs) are major transducer of signals across the plasma membrane. READ MORE

  2. 2. IGF-1R : Studies on the expression and role in transformation

    University dissertation from Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Author : Natalia Natalishvili; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Transformation is a complex nonlinear multistep process during which normal cell becomes cancerous. Main characteristics of transformed cells include uncontrolled growth, invasion and metastasis. READ MORE

  3. 3. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Camilla Hofström; KTH.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE

  4. 4. Affinity protein based inhibition of cancer related signaling pathways

    University dissertation from Stockholm : KTH

    Author : Erik Vernet; KTH.; [2009]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Abstract : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. READ MORE

  5. 5. SUMO and ubiquitin : The Yin and Yang of IGF-1R function

    University dissertation from Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Author : Bita Sehat; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor (IGF-1R) plays pivotal roles in cancer. READ MORE