Search for dissertations about: "IGF-1R"
Showing result 6 - 10 of 44 swedish dissertations containing the word IGF-1R.
-
6. The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways
Abstract : The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. READ MORE
-
7. The many faces of IGF-1R from cell surface to the nucleus
Abstract : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. READ MORE
-
8. IGF-1R inhibition : a tool for functional studies of insulin-like growth factor family in malignant cells
Abstract : Cancer cells generally posses the capability of overusing normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. Major players in extracellular signaling are the growth factor receptors. Among them, an activated IGF-1R is important for the establishment of a malignant cell phenotype. READ MORE
-
9. From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR
Abstract : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. READ MORE
-
10. The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma
Abstract : Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). READ MORE