Search for dissertations about: "IGF-II"

Showing result 1 - 5 of 31 swedish dissertations containing the word IGF-II.

  1. 1. Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma

    Author : Arash Hamidian; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2α; enChIP; ESRRA; mTORC2; IGF-II; Hypoxia; Cancer; PI3K; Transcription; Neuroblastoma;

    Abstract : Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. READ MORE

  2. 2. Early growth, retinopathy of prematurity and insulin-like growth factors in preterm infants

    Author : Eva Engström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Preterm; ROP; nutrition; growth; growth restriction; IGF-I; IGF-II; IGFBP-3;

    Abstract : Aims:Paper I: To perform measurements of the lower leg length (LLL) in preterm infants, compare and evaluate handling error and precision of two instruments, and estimate the time required to show growth.Paper II-IV: To investigate whether low postnatal levels of serum IGF-I are associated with abnormal retinal vessel development. READ MORE

  3. 3. Insulin-like growth factor II : Cellular effects through different receptors

    Author : Qimin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Insulin-like growth factor -II (IGF-II) and IGF-I are single-chain polypeptidesstructurally homologous to proinsulin and share similarities with insulin in functionalcharacteristics. Cellular actions of IGF-II are generally thought to be mediatedthrough the IGF-I or insulin receptors, but not the IGF-II receptor, which is a singlechain protein, identical to the cation independent mannose 6-phosphate (M6P) receptorand responsible for lysosomal enzyme targeting and degradation of IGF-II. READ MORE

  4. 4. Regulation of insulin-like growth factor-II in human liver

    Author : Henrik von Horn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; IG17-II; IGF2; IGFBPs; liver; hepatoblastoma; GH; hypoxia;

    Abstract : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. READ MORE

  5. 5. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Author : Sofie Mohlin; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Abstract : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. READ MORE