Search for dissertations about: "IGF-II"

Showing result 11 - 15 of 32 swedish dissertations containing the word IGF-II.

  2. 11. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    Author : Steven Gray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE

  4. 12. Exposures in utero and chronic disease : an alternative methodological approach

    Author : Anna Hübinette; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cardiovascular disease; acute myocardial infarction; angina pectoris; breast neoplasms; birth weight; birth anthropometrics; twin study; epidemiology; etiology; risk factors; insulin-like growth factors; preeclampsia; longitudinal study.;

    Abstract : The aims of this thesis were to evaluate maternal and birth characteristics as risk factors for breast cancer and cardiovascular disease later in life, and to assess maternal serum concentrations of insulin-like growth factors in pregnancies complicated by preeclampsia. Birth characteristics and risks of breast cancer were studied in a case-control study nested within the population-based Swedish Twin Register (Paper 1). READ MORE

  5. 13. Growth and integrity of the small intestine in malnutrition and trauma

    Author : Michael Wirén; Linköpings universitet; []
    Keywords : Glutamine; growth factors; intestinal mucosa; malnutrition; permeability; surgery; MEDICINE; MEDICIN;

    Abstract : The small intestine is an active metabolic organ constituting a functional and immunologic barrier to toxins and microbes in the intestinal lumen. Injuries are repaired by rapid cell replication, which depends on nutritional and humoral growth factors. Glutamine has been suggested to be the most important nutrient for the enterocytes. READ MORE

  6. 14. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Author : Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Abstract : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. READ MORE

  7. 15. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

    Author : Maria Gebre-Medhin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

    Abstract : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. READ MORE