Search for dissertations about: "IGF-II"

Showing result 21 - 25 of 32 swedish dissertations containing the word IGF-II.

  2. 21. Insulin-like Growth Factor System: functional role and regulation in carcinomas

    Author : Ann Rosendahl; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; PTEN; Transforming Growth Factor-beta; Insulin-like Growth Factor; Renal Cell Carcinoma; Cytologi; onkologi; cancer; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). READ MORE

  4. 22. Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation

    Author : Henric Zazzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF binding proteins IGFBP ; DNA sequencing; chromosomal localization; gene expression; Sp I; NF-kappa-B; methylation;

    Abstract : Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a family of binding proteins (IGFBPs) divided into subfamilies depending on their individual affinity for IGFs. READ MORE

  5. 23. Effects of growth factors on chondrocyte proliferation and differentiation

    Author : Caroline Edwall-Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Growth plate cartilage; limb buds; growth factors; proliferation; differentiation; collagens; c-fos; ALP;

    Abstract : Longitudinal bone growth is regulated at the level of growth plate chondrocytes by circulating or locally produced hormones and growth factors. Present investigation focused on the effects of growth hormone (GH) and growth factors on chondrocyte proliferation and differentiation during pre- and postnatal cartilage development. READ MORE

  6. 24. Insulin-like growth factor binding protein-3 : structure and function

    Author : Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin is secreted on demand depending on e. READ MORE

  7. 25. Matrix metalloproteases and cell motility in malignant mesothelioma

    Author : Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Abstract : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. READ MORE