Search for dissertations about: "IGF1"
Showing result 1 - 5 of 19 swedish dissertations containing the word IGF1.
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1. Genetic polymorphisms in breast cancer in relation to risk and prognosis
Abstract : Breast cancer is the most common cancer in women living in Sweden and the second most common cancer in the rest of the world. The risk of developing breast cancer is modified by environment, lifestyle, genetics and a combination of these factors. READ MORE
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2. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling
Abstract : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. READ MORE
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3. Targeting insulin-like growth factor-1 receptor in cancer
Abstract : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. READ MORE
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4. Prostate cancer aetiology : epidemiological studies of the IGF- and one-carbon metabolism pathways
Abstract : The aim of this thesis was to investigate the involvement of the insulin-like growth factor- and the one-carbon metabolism pathways in prostate cancer aetiology, studying both circulating biomarkers and genetic variation. Papers included in the thesis were conducted within the case-control study CAncer Prostate in Sweden (CAPS), and the two prospective studies European Prospective Investigation into nutrition and Cancer (EPIC), and Northern Sweden Health and Disease Cohort (NSHDC). READ MORE
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5. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families
Abstract : Breast cancer is the most common cancer among Swedish women, affecting more than 7000 women each year. About 5-10% of all breast cancers are hereditary, with a monogenic inheritance pattern, but only 2-4% are explained by germline mutations in BRCA1 or BRCA2. BRCA1/BRCA2 mutation carriers have a 60-80% risk of developing breast cancer. READ MORE