Search for dissertations about: "IGFBP- 1"

Showing result 11 - 15 of 59 swedish dissertations containing the words IGFBP- 1.

  2. 11. Genetic and epigenetic studies of diabetes and diabetic nephropathy with focus on the IGF-IGFBP axis

    Author : Tianwei Gu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes and diabetic nephropathy (DN) are complex diseases reflecting a complex interplay between genetic and non-genetic factors. The insulin-like growth factor (IGF) - IGF binding protein (IGFBP) axis plays an important role in the development of diabetes and DN. READ MORE

  4. 12. The HPA axis in type 2 diabetes : some aspects in relation to insulin sensitivity, beta-cell function and IGF-I/IGFBP-1

    Author : Lisa Arnetz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 2 diabetes (T2D) is characterized by insulin resistance and β-cell failure, abdominal obesity, hypertension and dyslipidemia. These symptoms are also characteristic of states of hypercortisolism. READ MORE

  5. 13. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Author : Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Insulin-like growth factor;

    Abstract : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. READ MORE

  6. 14. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Author : Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Abstract : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. READ MORE

  7. 15. Regulation and actions of insulin-like growth factor binding proteins in vascular smooth muscle cells

    Author : Thomas Gustafsson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Insulin-like growth factor-I (IGF-I) has multiple actions on vascular smooth muscle cell (VSMCs) function. In the circulation and in extracellular fluids, IGF-I is complexed to high affinity IGF-binding proteins (IGFBPs), which modulate IGF-I bioactivity. The present study focused on expression and regulation of IGFBPs in VSMCs. READ MORE