Search for dissertations about: "IGFBP-6"

Found 3 swedish dissertations containing the word IGFBP-6.

  2. 1. Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation

    Author : Henric Zazzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF binding proteins IGFBP ; DNA sequencing; chromosomal localization; gene expression; Sp I; NF-kappa-B; methylation;

    Abstract : Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a family of binding proteins (IGFBPs) divided into subfamilies depending on their individual affinity for IGFs. READ MORE

  4. 2. Neuropeptide expression in mouse disease models

    Author : Margarita Diez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimers disease; autoradiographic ligand binding; CCK; degeneration; dynorphin; enkephalin; galanin; immunohistochemistry; in situ hybridization; lesion; magnetic resonance imaging; megencephaly; NPY; prion infection; substance P.;

    Abstract : The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides (and other molecules). READ MORE

  5. 3. Spinal motoneurons and molecules related to neurotrophic function after axon injury

    Author : Henrik Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : immunohistochemistry; in situ hybridization; spinal cord; motoneuron; axotomy; survival; regeneration; MHC 1; leukocyte; cell culture; mRNA expression;

    Abstract : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. READ MORE