Search for dissertations about: "IKs"

Showing result 1 - 5 of 6 swedish dissertations containing the word IKs.

  2. 1. Mechanism of Action of the Antiarrhythmic Agent AZD7009

    Author : Frida Persson; Göteborgs universitet; []
    Keywords : atrial fibrillation; antiarrhythmic drug; IKr; IKur; Ito; IKs; IKACh; INa; ICaL; cardiac action potential; early afterdepolarisation;

    Abstract : Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration (APD) and the refractory period. READ MORE

  4. 2. Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart

    Author : Christian Danielsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. READ MORE

  5. 3. Development of AIDS associated and endemic Kaposi sarcoma : HHV-8/KSHV viral load in cutaneous and oral tumor cells

    Author : Fatemeh Pak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Oral Kaposi s sarcoma . HHV-8 . immunohistochemistry; PCR ; lymphatic ascular endothelium;

    Abstract : Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous lesion and eventually progresses to systemic disease usually in the gastrointestinal (G1) tract, lungs, oral cavity and lymph nodes. Whether KS represents a predominantly monoclonal neoplastic cell proliferation or a hyperplastic, reactive polyclonal process is still controversial. READ MORE

  6. 4. HHV-8/KSHV association with tumor cells during development of Kaposi sarcoma

    Author : Fatemeh Pak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous disease and progresses to extracutaneous, systemic spread usually in the gastrointestinal (GI) tract, lungs, oral cavity and lymph nodes. It is the most common neoplasm of AIDS patient and included in the staging of HIV disease progression. READ MORE

  7. 5. Kaposi's sarcoma and malignant lymphomas in Tanzania during the AIDS epidemic

    Author : Amos Rodger Mwakigonja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kaposi s sarcoma (KS) studies Kaposi´s sarcoma (KS) is the most frequent AIDS tumor (AKS) and associated with HHV-8, but controversial whether a clonal tumor or mostly a reactive proliferation of endothelial spindle cells (SC). In the present studies AKS and endemic KS (EKS) biopsies were compared for expression of HHV-8-LANA, the lymphatic endothelial (LEC) markers LYVE-1 and Ki-67 (proliferation). READ MORE