Search for dissertations about: "IL-1α"

Showing result 16 - 20 of 24 swedish dissertations containing the word IL-1α.

  2. 16. Regulation of T cells in Atherosclerosis

    Author : Megan Mulholland; Kardiovaskulär forskning - cellulär metabolism och inflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Atherosclerosis, the underlying pathology of cardiovascular diseases such as myocardial infarction and ischemic stroke, is characterized by chronic inflammation. T cells are present in atherosclerotic plaques and have been implicated in its pathogenesis. READ MORE

  4. 17. Dual cytokine inducing properties of HMGB1

    Author : Hulda Hreggvidsdottir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : High mobility group box protein 1 (HMGB1) is a nuclear protein that can be released either passively by necrotic cells or actively by stimulated cells. Extracellular HMGB1 is a potent inducer of inflammation and the importance of HMGB1 as a mediator in a number of inflammatory diseases including rheumatoid arthritis, sepsis and ischemia‐reperfusion injury, has been demonstrated by successfully targeting the protein in preclinical models. READ MORE

  5. 18. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS

    Author : Susanne Tingsborg; Fred J.H. Tilders; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. READ MORE

  6. 19. The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives

    Author : Natalia Nikolaitchouk; Göteborgs universitet; []
    Keywords : bacterial vaginosis; checkerboard DNA-DNA hybridisation; cytokines; SLPI; Lactobacillus coleohominis; Lactobacillus iners; Actinomyces urogenitalis;

    Abstract : Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known about the pathogenesis of BV. In BV, the normal vaginal Lactobacillus-dominated biota (LDB) is replaced by anaerobic bacteria. READ MORE

  7. 20. Multiple roles of HMGB1 in clinical and experimental arthritides

    Author : Hanna Schierbeck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammation can be infectious and/or sterile depending on the initiating event. The proinflammatory mediator High mobility group box protein 1 (HMGB1) is a nuclear protein released from cells during both sterile and infectious inflammation and once extracellular, initates and potentiates inflammation by inducing cytokine production and by recruiting inflammatory cells. READ MORE