Search for dissertations about: "IL-1β"
Showing result 1 - 5 of 156 swedish dissertations containing the word IL-1β.
-
1. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines
Abstract : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. READ MORE
-
2. Innate immunity in human atherosclerosis and myocardial infarction : Role of CARD8 and NLRP3
Abstract : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). READ MORE
-
3. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin
Abstract : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. READ MORE
-
4. Signal transduction pathways leading to apoptosis or necrosis in insulin-producing cells and prevention of cell death using gene transfer
Abstract : Signal transduction pathways potentially involved in destruction of insulin-producing β-cells in type-l diabetes and gene transfer to prevent β-cell death were studied in vitro. Adenovirus-polylysine/DNA complexes (AdpL) or polycationic liposomes mediated high reporter gene expression in dissociated primary human, fetal porcine, rat and mouse islet cells whereas gene transfer to intact islets was less efficient. READ MORE
-
5. Influence of inflammation and of stage of lung development on the development of neonatal lung injury
Abstract : Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological characteristics of BPD. Interleukin (IL)-1β is a central cytokine in inflammation. READ MORE
