Search for dissertations about: "IL-1β"

Showing result 16 - 20 of 164 swedish dissertations containing the word IL-1β.

  2. 16. Inflammatory response in equine joints : studies on proinflammatory cytokines in diseased joints and chondrocyte cultures

    Author : Cecilia Ley; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Proinflammatory cytokines mediate inflammatory responses as well as regulate tissue metabolism. Thus, they may provide a link between inflammation and other pathologic findings seen in equine joint disease. READ MORE

  4. 17. Chondrocyte and extracellular matrix alterations in equine cartilage during development and inflammation

    Author : Maria Löfgren; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Osteoarthritis (OA) is a disease involving inflammation and subsequent degeneration of joint tissues. The disease progresses with time-dependent stages of degeneration, loss and remodelling of the extracellular matrix (ECM) of articular cartilage, and phenotypical changes in the chondrocytes. READ MORE

  5. 18. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Author : Johnny Sternesjö; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. READ MORE

  6. 19. Experimental Studies Aiming to Prevent Type 1 Diabetes Mellitus

    Author : Tobias Rydgren; Stellan Sandler; Nils Welsh; Adrian Bone; Uppsala universitet; []
    Keywords : Cell biology; Diabetes; Interleukin-1 trap; Simvastatin; Nitric oxide synthase; Cytokine; Pancreatic islet; Streptozotocin; Transplantation; Cellbiologi;

    Abstract : Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which T-cells and macrophages invade the islets of Langerhans and selectively destroy the insulin producing β-cells, either directly or through the secretion of e.g. cytokines and nitric oxide (NO). This thesis has studied possible strategies to prevent T1DM. READ MORE

  7. 20. Mycobacterium tuberculosis and the human macrophage : shifting the balance through inflammasome activation

    Author : Daniel Eklund; Maria Lerm; Olle Stendahl; Eva Särndahl; Norbert Reiling; Linköpings universitet; []
    Keywords : ;

    Abstract : Mycobacterium tuberculosis is a very successful pathogen and tuberculosis constitutes a major threat to global health worldwide. The World Health Organization (WHO) estimates that almost nine million new cases and 1. READ MORE