Search for dissertations about: "IL-1 Ra"

Showing result 1 - 5 of 19 swedish dissertations containing the words IL-1 Ra.

  1. 1. Biologics in Staphylococcus aureus arthritis

    Author : Abukar Ali; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Staphylococcus aureus; CTLA4-Ig; IL-1 Ra; anti-TNF therapy; mouse; septic arthritis;

    Abstract : The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase the susceptibility of patients towards infections, such as septic arthritis. READ MORE

  2. 2. Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects

    Author : Lennart Boström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; gingival crevicular fluid; IL-1[beta]; IL-1ra; Il-6; periodontal bone height; periodontal surgery; periodontopathogens; TNF-[alpha]; smoking;

    Abstract : The main aim of the thesis was to evaluate the influence of smoking on the inflammatory response in periodontal disease. The overall study population included 347 patients: 224 men and 123 women, aged between 31-86 years, with moderate to severe periodontal disease. READ MORE

  3. 3. Immune mechanisms in atherosclerotic vascular disease

    Author : Jasmina Cvetkovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Atherosclerosis; rheumatoid arthritis; stroke; autoantibodies; pro-inflammatory cytokines;

    Abstract : Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory conditions found in rheumatoid arthritis. It entails an unregulated accumulation of lipids in the vessel wall, which leads to the development of cardiovascular diseases. READ MORE

  4. 4. Blocking interleukin-1 signalling in the brain-structural and functional outcomes

    Author : Stefan Spulber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). READ MORE

  5. 5. Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity

    Author : Mircea Oprica; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease (AD). Also, it was suggested that IL-1 is involved in physiological processes, namely modulation of sleep, glucose and lipid metabolism, and neuroendocrine regulation, as well as modulation of learning and memory. READ MORE