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Showing result 1 - 5 of 18 swedish dissertations matching the above criteria.

  2. 1. Biologics in Staphylococcus aureus arthritis

    Author : Abukar Ali; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; CTLA4-Ig; IL-1 Ra; anti-TNF therapy; mouse; septic arthritis;

    Abstract : The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase the susceptibility of patients towards infections, such as septic arthritis. READ MORE

  4. 2. Immune mechanisms in atherosclerotic vascular disease

    Author : Jasmina Cvetkovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; rheumatoid arthritis; stroke; autoantibodies; pro-inflammatory cytokines;

    Abstract : Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory conditions found in rheumatoid arthritis. It entails an unregulated accumulation of lipids in the vessel wall, which leads to the development of cardiovascular diseases. READ MORE

  5. 3. Blocking interleukin-1 signalling in the brain-structural and functional outcomes

    Author : Stefan Spulber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). READ MORE

  6. 4. Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity

    Author : Mircea Oprica; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease (AD). Also, it was suggested that IL-1 is involved in physiological processes, namely modulation of sleep, glucose and lipid metabolism, and neuroendocrine regulation, as well as modulation of learning and memory. READ MORE

  7. 5. Genetic control of myasthenia gravis : a study on cytokine and co-stimulator genes and their related functions

    Author : DeRen Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterised by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AchR) on the postsynaptic membrane of the neuromuscular junction. The aim of the study was to identify the role of the genes encoding potential immune components, such as TNF, IL-1, IL-1 receptor antagonist, IL-4, IL-10, and cytotoxic T lymphocyte antigen 4 (CTLA-4) in the pathogenesis of MG. READ MORE