Search for dissertations about: "IL-1"

Showing result 11 - 15 of 139 swedish dissertations containing the word IL-1.

  2. 11. The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer

    Author : Maria Seddighzadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Urinary bladder cancer; urokinase; urokinase receptor; interleukin-1;

    Abstract : Tumor invasion and metastasis are the major causes of cancer-related death. Proteases are important for the invasive and metastatic propensities of tumors. We have studied the mechanism underlying endogenous expression of the serine protease urokinase plasminogen activator (uPA) by human breast cancer cells. READ MORE

  4. 12. Mechanisms influencing activation and survival of normal and malignant lymphoid cells in the testis

    Author : Mikael von Euler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute lymphoblastic leukaemia; testis; cytokines; IL-1; TGFbeta;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and the testis is the third most common site of relapse after treatment. Testicular function is regulated by pituitary hormones, but the testicular microenvironment is also locally regulated through cell-cell interactions and by paracrine factors. READ MORE

  5. 13. Immunopathogenic mechanisms in inflammatory myopathies

    Author : Pernilla Englund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myositis; capillaries; muscle fibers; IL-1 alpha; MHC; adhesion molecules;

    Abstract : The idiopathic inflammatory myopathies (IIMs) are characterized by symmetrical, proximal muscle weakness and by inflammatory infiltrates in muscle tissue. Based on different clinical as well as histopathological features the IlMs can be separated into polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). READ MORE

  6. 14. Neuro-immune communication: role of the vagus nerve : an electrophysiological study

    Author : Violeta Bucinskaite; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cholecystokinin; CCKA; CCKB; cytokines; IL-1[beta]; illness; nerve activity; NIDDM; OLETF; the vagus; vagotomy;

    Abstract : Defence mechanisms involve close interactions between the nervous and immune systems following an immune challenge. The vagal pathways which modulate major visceral functions under normal conditions are also important neural pathways for the transmission of information on peripheral conditions to the CNS. READ MORE

  7. 15. Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects

    Author : Lennart Boström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : gingival crevicular fluid; IL-1[beta]; IL-1ra; Il-6; periodontal bone height; periodontal surgery; periodontopathogens; TNF-[alpha]; smoking;

    Abstract : The main aim of the thesis was to evaluate the influence of smoking on the inflammatory response in periodontal disease. The overall study population included 347 patients: 224 men and 123 women, aged between 31-86 years, with moderate to severe periodontal disease. READ MORE