Search for dissertations about: "IL-1"

Showing result 16 - 20 of 139 swedish dissertations containing the word IL-1.

  2. 16. Molecular and functional studies of interleukin-1a in the rat testis

    Author : Taranum Sultana; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Interleukin-l alpha; spermatogenesis; Leydig cells; Sertoli cells; calpain I and II;

    Abstract : The aim of the present study was to gain a better insight into the role of interleukin-1 alpha (IL-1 alpha) in testicular physiology. In testis, IL-1alpha acts as a paracrine mediator involved in the regulation of testicular functions. READ MORE

  4. 17. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS

    Author : Susanne Tingsborg; Fred J.H. Tilders; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. READ MORE

  5. 18. Studies of cytokine mediated regulation of central nervous functions : role of prostaglandins

    Author : Monica Ek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : interleukin-1; prostaglandin E2; central nervous system; HPA axis; fever; vagus nerve;

    Abstract : The communication between the immune system and the central nervous system (CNS) results in an array of centrally regulated illness responses, including fever and increased hypothalamus-pituitary-adrenal (HPA) axis activity. The mechanisms by which the immune system signals the brain across the blood-brain barrier have not been completely elucidated, but proinflammatory cytokines, like interleukin-1 (IL-1), are believed to act as important mediators. READ MORE

  6. 19. Interleukin-1 Receptors and their Ligands

    Author : David Malinowsky; Gordon W Duff; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : Interleukin-1 (IL-1) is an endogenous mediator of the inflammatory response. IL-1 executes its actions by binding and subsequent activation of the IL-1 receptor (IL-1R) proteins. Among the many systemic effects of IL-1, the fever response was the first to be investigated. READ MORE

  7. 20. Blocking interleukin-1 signalling in the brain-structural and functional outcomes

    Author : Stefan Spulber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). READ MORE